Bochkis Lab

Wei X, Murphy MA, Reddy NA, Hao Y, Eggertsen TG, Saucerman JJ, Bochkis IM.Redistribution of lamina-associated domains reshapes binding of pioneer factor FOXA2 in development of nonalcoholic fatty liver disease. Genome Research. 2022 Dec 15. doi: 10.1101/gr.277149.122. PMID: 36522168

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Kain J,  Wei X, Reddy NA, Price AJ, Woods C,  Bochkis IM. Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα. Molecular Metabolism. 2021. Nov;53:101291.

doi: 10.1016/j.molmet.2021.101291. Epub 2021 Jul 8. PMID: 34246806  PMCID: PMC8350412

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Price AJ, Manjegowda MC, Kain J, Anandh S, Bochkis IM. Hdac3, Setdb1, and Kap1 mark H3K9me3/H3K14ac bivalent regions in young and aged liver. Aging Cell. 2020;19(2):e13092. doi:10.1111/acel.13092

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Whitton H, Singh LS, Patrick MA, Price AJ, Osorio FG, Lopez-Otin C, Bochkis IM, Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver, 2018; Aging  Cell. Jun;17(3):e12742. doi: 10.1111/acel.12742. Epub 2018 Feb 27. PMID:29484800,  PMCID: PMC5946061

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Bochkis IM, Przybylski D, Chen J, Regev A, Changes in nucleosome occupancy associated with metabolic alterations in aged mammalian liver., 2014; Cell reports. 9(3) 996-1006. PMID: 25437555, PMCID: PMC4250828.

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Bochkis IM, Shin S, Kaestner KH, Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity., 2013; Molecular metabolism. 2(4) 447-56. PMID: 24327960, PMCID: PMC3855091.

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Bochkis IM, Schug J, Ye DZ, Kurinna S, Stratton SA, Barton MC, Kaestner KH, Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2., 2012; PLoS genetics. 8(6) e1002770.  PMID: 22737085, PMCID: PMC3380847.

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Bochkis IM, Schug J, Rubins NE, Chopra AR, O’Malley BW, Kaestner KH, Foxa2-dependent hepatic gene regulatory networks depend on physiological state., 2009; Physiological genomics. 38(2) 186-95.  PMID: 19417011, PMCID: PMC2712224.

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Bochkis IM, Rubins NE, White P, Furth EE, Friedman JR, Kaestner KH, Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress., 2008; Nature medicine. 14(8) 828-36. PMID: 18660816, PMCID: PMC4095974.

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Behr R, Sackett SD, Bochkis IM, Le PP, Kaestner KH, Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3., 2007; Developmental biology. 306(2) 636-45. PMID: 17488644, PMCID: PMC1952241.

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Phuc Le P, Friedman JR, Schug J, Brestelli JE, Parker JB, Bochkis IM, Kaestner KH, Glucocorticoid receptor-dependent gene regulatory networks., 2005; PLoS genetics. 1(2) e16. PMID: 16110340, PMCID: PMC1186734.