Our laboratory is investigating how cellular processes govern proper metabolic function and how abnormal physiology leads to metabolic disease. In particular, we apply experimental and computational methods to identify genetic and epigenetic mechanisms regulating metabolism. We are focusing on understanding how genome-wide chromatin changes, which include chromatin accessibility, nuclear localization and dynamics, and genome organization, lead to physiological dysfunction. Our laboratory utilizes functional genomics, chromatin biology, physiology, and transcriptional regulation in a comprehensive approach to decipher molecular mechanisms in mammalian models of human metabolic disease.
Our lab is moving to University of Pittsburgh School of Medicine Liver Research Center. Everyone is staying on and excited about new opportunities
Our HiChIP paper has been accepted for publication at Cellular and Molecular Gastroenterology and Hepatology (CMGH). Congratulations
Yi and first-time authors Lulu and Carol! The paper is available online
Welcome to ChIP Week 2023! 5 days, 3 labs, 4 antibodies, 0 sharks. Thanks to Joe for hosting Anjana from Anakk lab at University of Illinois Urbana Champaign and Gabriella from Vallim lab at UCLA.
Our summer rotation student starts in the lab. Welcome Seth!
Our PI Irina has been promoted to Associate Professor! Congratulations!
Our work is featured here
Our preprint on Foxa2 HiChIP is available online. Congratulations Lulu and Carol!
More coverage of our lamina paper
Press release on our lamina paper is found here
Also, coverage in Department of Pharmacology
December 15, 2022
Our lamina paper is available online
November 16, 2022
Our lamina paper has been accepted for publication at Genome Research! Congratulations Tom, Megan, Nihal, and Yi!
September 27, 2022
Started a collaboration with Saucerman Lab for revision of our lamina paper
July 15, 2022
Our collaborative paper with Leitinger Lab is published. Congratulations Clint!
July 7, 2022
Our collaborative paper with Harris lab is published. Congratulations Mitch!
June 26-30, 2022
Joe attends his first conference, FASEB Liver Meeting in New Orleans
June 10, 2022
Joe starts as a post-baccalaureate researcher. We look forward to seeing your talent grow!
June 6, 2022
Two new students join the lab. Welcome Carol and Lulu!
May 21, 2022
Joe and Abel graduate! Congratulations!