Our laboratory is investigating how cellular processes govern proper metabolic function and how abnormal physiology leads to metabolic disease. In particular, we apply experimental and computational methods to identify genetic and epigenetic mechanisms regulating metabolism. We are focusing on understanding how genome-wide chromatin changes, which include chromatin accessibility, nuclear localization and dynamics, and genome organization, lead to physiological dysfunction. Our laboratory utilizes functional genomics, chromatin biology, physiology, and transcriptional regulation in a comprehensive approach to decipher molecular mechanisms in mammalian models of human metabolic disease.


Lab News

July 29

Press release and press coverage of our paper



July 26

Our new Research Scientist Yi Hao joined the lab. Welcome Yi!


July 8

Our paper on the role of Foxa2 in ligand-dependent activation of nuclear receptors is accepted and available online


Congratulations to co-first author Tom Wei and first time authors Nihal Reddy and Claire Woods!

July 1

MSTP student Avery Sukienik has joined us for a summer rotation. Welcome Avery!

June 15, 2021

Joseph Schinderle, Summer Diabetes Research intern, has joined us for the summer. Welcome Joseph!

June 2, 2021

We are hiring!  We are looking for a Research Scientist to join our team


May 17, 2021

Lab Specialist Jacob Turner joined our lab. Welcome Jacob!

May 9, 2021

Congratulations to  undergraduate researchers Claire Woods and Megan Murphy on their graduation!

April 10, 2020

Preprint of our new manuscript is posted online at bioRxiv  https://biorxiv.org/cgi/content/short/2020.04.10.036061v1

December 19, 2019

Our paper is online! https://onlinelibrary.wiley.com/doi/10.1111/acel.13092

November 23, 2019

Our bivalent marks paper has been accepted for publication in Aging Cell! It's been a great month for lab successes!

November 15, 2019

National Institute of Diabetes and Digestive and Kidney Diseases is funding our first R01 application!